中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (3): 147-149.

• 论著 • 上一篇    下一篇

痤疮患者血清H2S水平变化及与IL-6和TNF-α相关性

王玉1 黄霞1 余晶晶1,2   

  1. 湖北省十堰市人民医院皮肤科；2湖北医药学院
  • 出版日期:2016-03-15 发布日期:2018-12-19
  • 通讯作者: 余晶晶，E-mail: 13317283066@163.com

Changes of hydrogen sulfide and its correlation with interleukin 6 and tumor necrosis factor-α in patients with acne

WANG Yu, HUANG Xia, YU Jingjing.   

  1. 1.Department of Dermatology, Shiyan People’s Hospital, Hubei 442000, China; 2.Hubei University of Medicine, Shiyan 442000, China;
  • Online:2016-03-15 Published:2018-12-19
  • Contact: YU Jingjing, E-mail: 13317283066@163.com

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摘要： 目的: 明确痤疮患者血浆H2S水平变化及与IL-6和TNF-α的相关性。方法: 采用亚甲基染色法检测67例痤疮患者（轻度31例、中度21例、重度15例）及20名健康体检者血清H2S水平， ELISA检测血清IL-6和TNF-α水平。结果:痤疮患者血清H2S平均水平为（13.79±4.19）μ mmol/L 显著低于对照组的（22.23±4.52）μ mmol/L（P<0.001)；血清IL-6及TNF-α平均水平分别为（89.72±31.68）pg/mL及（61.17±23.81）pg/mL高于对照组的（27.32±4.26 ）pg/mL和(22.73±14.33 pg/mL)（均P<0.001)。痤疮患者血浆H2S水平与IL-6和TNF-α浓度均呈显著负相关(均P<0.001)。结论:血浆H2S可能参与痤疮炎症的发病过程。

关键词: 痤疮, 硫化氢, IL-6, TNF-α

Abstract: Objective: To detect the level of hydrogen sulfide (H2S) and determine the relationship of H2S with IL-6 and TNF-α．Methods: The level of H2S in 67 patients with acne vulgaris (31 patients with mild acne, 21 with moderate acne and 15 with severe acne) and 20 normal controls was detected by methylene blue staining. The level of IL-6 and TNF-α were detected by ELISA. Results: The average level of H2S in patients with acne was （13.79±4.19） μmmol/L, which was lower than that of controls (22.23±4.52 μmmol/L). The average levels of IL-6 and TNF-α were （89.72±31.68）pg/mL and (61.17±23.81) pg/mL, which was higher than those of controls (27.32±4.26 pg/mL and 22.73±14.33 pg/mL)．The H2S level of patients was negative correlated with the levels of IL-6 and TNF-α (P<0.001). Conclusion: H2S may be associated with the inflammation reaction in the course of acne. .

Key words: acne, hydrogen sulfide, IL-6, TNF-α