308-nm准分子激光联合他克莫司软膏治疗面部白癜风656例疗效评价

中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (5): 281-283.

308-nm准分子激光联合他克莫司软膏治疗面部白癜风656例疗效评价

法莹1，2，刘华绪1

1 济南大学山东省医学科学院医学与生命科学学院，济南，250062 2山东省皮肤病性病防治研究所，济南，250022

出版日期:2016-05-15 发布日期:2018-12-25
通讯作者: 刘华绪 liueternal@163.com
基金资助:
国家自然科学基金（编号：81271773）

Assessment of the 308nm excimer laser combined with topical tacrolimus in the treatment of facial vitiligo

FA Ying1,2, LIU Huaxu1.

1.School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences, Jinan 250062，China； 2. Shandong Provincial Institute of Dermatology and Venereology,Provincial Academy of Medical Science,Jinan 250022, China

Online:2016-05-15 Published:2018-12-25
Contact: LIU Huaxu, E-mail: liueternal@163.com

摘要/Abstract

摘要： 目的：评价308nm准分子激光联合他克莫司软膏治疗面部白癜风的疗效。方法：对656例面部白癜风患者照射308nm准分子激光联合外用他克莫司软膏。他克莫司软膏每日2次，308nm准分子激光每周治疗1-2次，共治疗30次。末次治疗后随访1年。结果：1630块白斑中，总有效率为47.12%，病程<2年皮损总有效率为58.10%高于病程≥2年皮损的16.60%，两组差异具有统计学意义(P<0.001)。眼周皮损疗效最佳，总有效率为54.96%，口周皮损疗效最差，总有效率为40.22%，差异有统计学意义（P<0.0001）。结论：308 nm准分子激光联合他克莫司软膏治疗面部白癜风的疗效与病期和皮损部位有关。

关键词: 白癜风, 308 nm准分子激光, 他克莫司

Abstract: Objective: To assess the efficacy of 308nm excimer laser combined with topical tacrolimus in the treatment of facial vitiligo. Methods: Six hundred and fifty six patients were treated with topical tacrolimus twice a day and 308nm excimer laser once or twice a week for 30 times. The patients were followed up for 1 year. Results: The total effective rate of 1630 lesions was 47.12%. The effective rate of the lesions with a duration of illness less than 2 years was 58.10%, which was higher than that for the lesions with a duration of illness more than 2 years (16.6%), with a significant difference (P<0.001). The curative effect for the lesion in the periocular area was 54.96%, while the effect for the perioral lesions was 40.22%, with a significant difference between the two groups (p < 0.0001). Conclusion: The therapeutic effect of 308nm excimer laser combined with tacrolimus in the treatment of facial vitiligo depends on the duration and location of the lesion.

Key words: vitiligo, 308-nm excimer laser;tacrolim

法莹, 刘华绪. 308-nm准分子激光联合他克莫司软膏治疗面部白癜风656例疗效评价[J]. 中国麻风皮肤病杂志, 2016, 32(5): 281-283.

FA Ying, LIU Huaxu.. Assessment of the 308nm excimer laser combined with topical tacrolimus in the treatment of facial vitiligo [J]. China Journal of Leprosy and Skin Diseases, 2016, 32(5): 281-283.

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