中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (6): 339-341.

• 论著 • 上一篇    下一篇

慢性自发性荨麻疹维生素D和部分急性时相反应物的检测

马一平 李诚让 吴建兵 崔盘根 林麟   

  1. 中国医学科学院皮肤病研究所 南京 210042
  • 出版日期:2016-06-15 发布日期:2018-12-27
  • 通讯作者: 马一平，E-mail:mayipingg@sohu.com

Detection of the levels of vitamin D and some acute phase response pattern in the patients with chronic spontaneous urticaria

MA Yiping,LI Chengrang,WU Jianbing, CUI Pangen, LIN Lin.   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing 210042，China
  • Online:2016-06-15 Published:2018-12-27
  • Contact: MA Yiping, E-mail: mayipingg@sohu.com

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摘要： 目的：明确维生素D与超敏C反应蛋白(CRP)、补体C3、C4水平和慢性自发性荨麻疹(CSU)严重程度的关系。方法：检测50例CSU患者和30名健康对照者25( OH) D和超敏C反应蛋白(CRP)、补体C3、C4水平,并对患者进行病情严重程度评分（UAS7）。结果：CSU组25( OH) D血清浓度明显低于健康对照组，CSU患者CRP、C3、C4水平明显高于健康对照组。25( OH) D血清浓度与UAS7评分呈负相关，与CRP、C3、C4之间无明显相关性。结论：维生素D的水平与慢性荨麻疹病情相关。

关键词: 荨麻疹, 维生素D, 补体

Abstract: Objective: To determine the relationship among vitamin D level, and C3, C4 and CRP concentrations and the disease severity of chronic spontaneous urticaria. Methods: Concentrations of CRP, C3, C4 and 25-hydroxyvitamin D [25(OH) D] were detected in 55 patients and 30 healthy controls. The disease severity score (UAS7) was assessed clinically. Results: The level of serum 25(OH) D in CSU patients was significantly lower than that in controls and the concentrations of CRP, C3 and C4 were significantly higher than those in controls. There was a negative correlation between the level of 25(OH) D and UAS7 score in the patients and there was no correlation between the levels of 25(OH) D, and the concentration of CRP, C3 and C4. Conclusion: The serum level of 25(OH) D is associated with the severity of CSU.

Key words: urticaria, vitamin D, complement