中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (2): 122-124.

• 综述 • 上一篇    下一篇

抗菌肽LL-37 与皮肤病的相关性研究

陈晋广 蔡天国 林兰英 郑昌竹   

  1. 台州市中心医院皮肤科，浙江省台州市，318000
  • 出版日期:2018-02-15 发布日期:2018-12-06
  • 通讯作者: 陈晋广，E-mail：tongly0422@126.com
  • 基金资助:

    浙江省卫计委（编号：2012KYA184，2013KYA231）；浙江省中管局（编号：2012ZA131，2017ZB097）

The role of antimicrobial peptide LL-37 in dermatology

CHEN Jinguang，CAI Tianguo，LIN Lanying，ZHENG Changzhu.   

  1. Taizhou Municipal Central Hospital, Taizhou, 318000, China
  • Online:2018-02-15 Published:2018-12-06

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摘要： 抗微生物肽LL-37在先天性免疫防御中发挥重要作用,因其具有多种生物学活性，在免疫性疾病和感染疾病方面的研究成为热点。近年研究提示，LL-37可能通过影响巨噬细胞、中性粒细胞、免疫等功能而参与多种皮肤病的病理生理过程。LL-37及其衍生物在多种皮肤病的临床应用也有广阔的研究前景。本文就LL-37的功能、LL-37 与常见皮肤病的关系等研究进展作一综述。

关键词: LL-37, 抗菌肽, 先天免疫, 皮肤病

Abstract: The human anti-microbial peptide LL-37 is an integral part of innate immune and LL-37 has multiple bioactivities. It has been intensively investigated in the field of immunity and inflammation. It is reported that LL-37 is related to the pathophysiology of skin diseases in recent researches. LL-37 may be involved in the pathogenesis of skin diseases by modulating the function of macrophages, neutrophils and immunity. The prognostic and therapeutic values of LL-37 and its derivatives for skin diseases are intriguing and should be further investigated.?The function of LL-37 in the pathogenesis of skin diseases is reviewed in this article.

Key words: LL-37, antimicrobial peptide, innate immunity, dermatology