中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (7): 403-406.

• 论著 • 上一篇    下一篇

TNF-α启动子区单核苷酸多态性与中国维吾尔族白癜风的相关性

王晓朋1 吴秀娟2赵宗峰2 王鹏2 布瓦杰尔.亚克亚2 普雄明2康晓静2   

  1. 1.新疆石河子大学，石河子，832000 2.新疆维吾尔自治区人民医院皮肤科，乌鲁木齐，830001
  • 出版日期:2018-07-15 发布日期:2018-12-14
  • 通讯作者: 吴秀娟，E-mail: xjwuxj@sina.com；康晓静，E-mail:drkangxj666@163.com

Association of single nucleotide polymorphism of TNF-α and vitiligo in the patients of Uygur nationality in China

WANG Xiaopeng1, WU Xiujuan2, ZHAO Zongfeng2, WANG Peng2 , YAKEYA.Buwajieer2, PU Xiongming2 , KANG Xiaojing2   

  1. 1.Shihezi University, Shihezi 832000, China;, 2.Xinjiang Uygur Autonomous Region People's Hospital, Urumchi 830001, China
  • Online:2018-07-15 Published:2018-12-14
  • Contact: WU Xiujuan, E-mail: xjwuxj@sina.com;KANG Xiaojing，E-mail:drkangxj666@163.com

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摘要： 目的：明确TNF-α启动子区基因多态性与中国维吾尔族白癜风发病机制的相关性。方法： PCR扩增316例维吾尔族白癜风患者和330例健康对照组外周血目的片段DNA，DNA 全自动测序仪对TNF-α启动子区基因rs1799964、rs1800630、rs1799724 三个位点单核苷酸基因多态性进行测序。结果：白癜风患者TNF-αrs1799964、rs1800630、rs1799724基因型和等位基因频率与对照组比较均无统计学意义（P＞0.05）。TNF-α rs1799724 基因型及T等位基因频率在白癜风早发型与迟发型间、有无家族史间比较，差异均有统计学意义（均P＜0.05)。结论：TNF-α 启动子区rs1799724位点单核苷酸多态性可能参与中国维吾尔族白癜风的发生和发展。

关键词: 白癜风, 肿瘤坏死因子-a, 单核苷酸多态性, 启动区

Abstract: Objective: To determine the association of TNF-αsingle nucleotide polymorphisms (SNP) and vitiligo in the patients of Uygur nationality in China. Methods: The aim gene fragment extracted from the peripheral blood DNA of 316 uygur patients with vitiligo and 330 uygur healthy controls. Three loci polymorphisms rs1799964, rs1800630, rs1799724 in TNF-αpromoter were detected by the sequencing method. Results: There was no significant differences in the frequency of rs1799964, rs1800630 and rs1799724 between the patients and controls (P＞0.05). There were significant differences in the rs1799724 T allele frequency between the patients with early-onset and late-onset among the patients with?and without?family history (Ps<0.05). Conclusion: TNF-α promoter rs179972a SNP may be associated with vitiligo in Chinese uygur.

Key words: vitiligo, tumor necrosis factor - a, single nucleotide polymorphism, promoter