中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (1): 61-64.doi: 10.12144/zgmfskin202301061

• 综述 • 上一篇    下一篇

婴幼儿血管瘤发病机制研究进展

刘小烨,齐蔓莉   

  1. 天津医科大学总医院皮肤科，天津，300000
  • 出版日期:2023-01-15 发布日期:2022-11-28

Update of pathogenesis of infantile hemangiomas

LIU Xiaoye, QI Manli   

  1. Tianjin Medical University General Hospital, Tianjin 300000, China
  • Online:2023-01-15 Published:2022-11-28

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摘要： 婴幼儿血管瘤（infantile hemangioma，IH）是一种常见的血管异常性疾病，目前对于IH的发病机制，尤其是自行消退的机制尚不十分清楚。研究发现血管瘤的内皮细胞与胎盘来源的血管内皮祖细胞具有同源性，遗传易感性、一些血管生成调节因子、细胞因子、转录因子、信号通路及基因在IH的发病机制中发挥着重要作用。本文就IH发病机制研究进展进行综述，以期为IH的治疗提供新的思路。

关键词: 婴幼儿血管瘤, 细胞因子, 转录因子, 信号通路, 基因

Abstract: Infantile hemangioma is a common abnormal vascular disease. At present, the pathogenesis of IH, especially the mechanism of its spontaneous regression, both are not very clear. Study found that the endothelial cells of hemangioma have homology with placenta-derived vascular endothelial progenitor cells. Genetic susceptibility, some angiogenesis regulators, cytokines, transcription factors, signaling pathways and genes play an important role in the pathogenesis of IH. The update of the pathogenesis of IH is reviewed in this paper, in order to provide new ideas for the treatment of IH.

Key words: infantile hemangioma, cytokine, transcription factor, signal pathway, gene