中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (10): 741-743.doi: 10.12144/zgmfskin202510741

• 病例报告 • 上一篇    下一篇

误诊为脂肪瘤的球形孢子丝菌感染一例

黄晓慧1,2,吴瑕1,朱恒3,杨琛儿1,钟伟龙1,邵勇1,黄海艳1   

  1. 1北京大学深圳医院皮肤科，广东深圳,518036; 2南方科技大学，广东深圳,518055;3北京大学深圳医院检验科，广东深圳,518036
  • 出版日期:2025-10-15 发布日期:2025-09-28

Sporothrix globosa infection misdiagnosed as lipom: a case report

HUANG Xiaohui1,2, WU Xia1, ZHU Heng3, YANG Chen'er1, ZHONG Weilong1, SHAO Yong1, HUANG Haiyan1   

  1. 1 Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen 518036, China; 2 Southern University of Science and Technology, Shenzhen 518055, China; 3 Department of laboratory, Peking University Shenzhen Hospital, Shenzhen 518036, China
  • Online:2025-10-15 Published:2025-09-28

PDF (PC)

17

摘要： 患者,女，53岁，上臂多发红色结节、斑块及溃疡4个月。外科首诊“脂肪瘤”并切除皮损,切除标本病理示慢性炎症，术后2周术区出现红色结节伴溃疡，迁延4个月未愈。后就诊于皮肤科，复切新皮损组织病理示感染性肉芽肿，真菌培养及m-NGS高通量测序鉴定为球形孢子丝菌，对外科首次切除标本追加PAS染色可见少量真菌孢子。予口服伊曲康唑胶囊治疗，3个月后皮损显著改善，仍在治疗中。本例提示早期孢子丝菌病极易误诊，对术后持续炎症或溃疡应尽早行真菌学检查，以免漏诊延误。

关键词: 孢子丝菌病, 球形孢子丝菌, 皮肤感染, 脂肪瘤

Abstract: A 53-year-old female patient presented with multiple red nodules, plaques and ulcers on her upper arm for 4 months. She was first diagnosed with “lipoma” in the surgery department and underwent resection of the lesions. Pathological examination of the resected specimen showed chronic inflammation. Two weeks after the operation, red nodules with ulcers appeared in the surgical area, which persisted for 4 months without healing. Then, she consulted the dermatology department, and the histopathology of the re-excised new lesion showed infectious granuloma. Sporothrix globosa was identified by fungal culture and m-NGS high-throughput sequencing. Additional PAS staining of the first surgical resection specimen from the surgery department revealed a small number of fungal spores. The patient was given oral itraconazole capsules for treatment, and the lesions improved significantly after 3 months, and the treatment is still ongoing. This case suggests that early sporotrichosis is easily misdiagnosed, and mycological examinations should be performed as early as possible for persistent postoperative inflammation or ulcers to avoid missed diagnosis and delay in treatment.

Key words: sporotrichosis, Sporothrix globosa, cutaneous infection, lipoma