中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (3): 179-181.doi: 10.12144/zgmfskin202303179

• 病例报告 • 上一篇    下一篇

硬皮病样慢性移植物抗宿主病一例

赖俊东,龙小换,张琪,江慧姗,王卫亮   

  1. 阳江市人民医院皮肤科，广东阳江，529500
  • 出版日期:2023-03-15 发布日期:2023-02-16

Scleroderma-like chronic graft-versus-host disease: a case report

LAI Jundong, LONG Xiaohuan, ZHANG Qi, JIANG Huishan, WANG Weiliang   

  1. Department of Dermatology, The People's Hospital of Yangjiang, Yangjiang 529500, China
  • Online:2023-03-15 Published:2023-02-16

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摘要： 患者，男，42岁。全身红斑、硬化、脱发9年。皮肤科查体：胸部、四肢、鼻周、口周等部位地图样斑块、色素脱失斑、萎缩、瘢痕，头顶部见脱发区，表面见色素脱失。腹部皮损组织病理示：表皮角化过度，基底细胞空泡变性伴色素失禁；真皮附属器减少，真皮浅层胶原纤维粗大、致密及玻璃样变。诊断：硬皮病样慢性移植物抗宿主病。

关键词: 移植物抗宿主病, 慢性, 硬皮病

Abstract: A 42-year-old male presented with erythema, sclerosis, and hair loss for 9 years. Mainly lesions manifested as anomalous plaques, depigmented spots, atrophy, and scars on the chest, limbs and face, hair loss and depigmentation on the top of head. Histopathological manifestations of abdominal lesions showed hyperkeratosis of the epidermis, vacuolar degeneration of basal cells with pigment incontinence, reduction of dermal appendages, thickening of collagen, and hyaline degeneration. The diagnosis of scleroderma-like chronic graft-versus-host disease was made.

Key words: graft-versus-host disease, chronic, scleroderma