中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (7): 538-542.doi: 10.12144/zgmfskin202307538

• 综述 • 上一篇    下一篇

药物超敏反应综合征的发病机制及治疗进展

杨娈,温禾,孙青   

  1. 山东大学齐鲁医院皮肤科，济南，250012
  • 出版日期:2023-07-15 发布日期:2023-07-05

Pathogenesis and therapeutic advances of drug induced hypersensitivity syndrome

YANG Luan, WEN He, SUN Qing   

  1. Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, China
  • Online:2023-07-15 Published:2023-07-05

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摘要： 药物超敏反应综合征(DIHS)是一种严重的药物不良反应，病因可能与遗传易感性、药物代谢酶缺乏、免疫反应异常及病毒再激活等因素相关。传统治疗主要包括糖皮质激素、免疫抑制剂、静脉注射免疫球蛋白、抗病毒及血浆置换等。近年来随着药物超敏反应综合征的研究取得了一定进展，小分子靶向药及生物制剂也成功用于DIHS的治疗。本文就DIHS的发病机制及治疗进展进行综述。

关键词: 物超敏反应综合征, 伴嗜酸粒细胞增多和系统症状的药物反应, 发病机制, 治疗

Abstract: Drug induced hypersensitivity syndrome (DIHS) is a severe adverse drug reaction. Genetic susceptibility, drug-metabolizing enzymes deficiency, immune changes and virus reactivation may be involved in the etiology of DIHS. The traditional treatment includes glucocorticoids, immunosuppressant, intravenous immunoglobulin, plasmapheresis and so on. The research of DIHS has made certain progress and the application of targeted small-molecule inhibitors and biologic agents have been used successfully to treat DIHS in recent years. The pathogenesis and therapeutic advances of DIHS are reviewed in this paper.

Key words: drug induced hypersensitivity syndrome, drug reaction with eosinophilia and systemic symptoms, pathogenesis, treatments