中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (7): 385-389.

• 论著 •    下一篇

CD163+肿瘤相关巨噬细胞在常见上皮性皮肤肿瘤中的分布

周文明1，2，汪宇1,张伟 1，申小平1，刘志1，李世军1，陆洪光1   

  1. 1贵州医科大学附属医院皮肤科，贵州贵阳,550004
    2贵州省铜仁市人民医院，贵州铜仁,554300
  • 出版日期:2017-07-15 发布日期:2018-12-01
  • 通讯作者: 陆洪光，E-mail：hongguanglu@hotmail.com

Detect of CD163+ tumor associated macrophages in common skin epithelial tumors

ZHOU Wenming1，2, ZHANG Wei1, SHEN Xiaoping1, LIU Zhi1, LI Shijun1, LU Hongguang1   

  1. 1. Department of Dermatology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004,China; 2. People's Hospital of Tongren, Guizhou, Tongren 554300, China
  • Online:2017-07-15 Published:2018-12-01
  • Contact: LU Hongguang, E-mail：hongguanglu@hotmail.com

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摘要： 目的：检测CD163+肿瘤相关巨噬细胞在皮肤鳞状细胞癌、基底细胞癌、鲍温病、日光性角化病中的分布。方法：采用免疫组织化学法(MaxVision法)检测CD163标记的肿瘤相关巨噬细胞在正常皮肤、鳞状细胞癌、基底细胞癌、鲍温病、日光性角化病中的分布。结果：每高倍镜视野下正常皮肤、鲍温病、日光性角化病真皮浅层中CD163+巨噬细胞个数为(9.5000±1.71594)、(43.9200±9.98716)和(49.4000±8.73830)个;基底细胞癌肿瘤间质中为(42.1724 1±11.73234)，鳞状细胞癌的肿瘤间质中及肿瘤实质内为(65.8421±14.05649)。结论：CD163+肿瘤相关巨噬细胞可能与皮肤上皮性肿瘤的发生、发展相关。

关键词: 肿瘤相关巨噬细胞, 皮肤鳞状细胞癌, 基底细胞癌, 鲍温病, 日光性角化病, CD163

Abstract: Objective: To detect the distribution of CD163+ tumor associated macrophage in skin squamous cell carcinoma, basal cell carcinoma, Bowen's disease and actinic keratosis. Methods: The distribution of CD163+ tumor associated macrophages under in the normal skin,skin squamous cell carcinoma, basal cell carcinoma, Bowen's disease and actinic keratosis were detected by the immunohistochemitry method (MaxVision). Results: The number of CD163+ tumor associated macrophage in the upper dermis of the normal skin, Bowen's disease and actinic keratosis were (9.5000±1.71594), (43.9200±9.98716) and (49.4000±8.73830) respectively and 42.17241±11.73234 in the tumor stroma of basal cell carcinoma, 65.8421±14.05649 in the tumor stroma and parenchyma of the skin squamous cell carcinoma. Conclusion: The CD163+ tumor associated macrophages may play an important role in the occurrence and development of the common skin epithelial tumors.

Key words: tumor associated macrophage, skin squamous cell carcinoma, basal cell carcinoma, Bowen's disease, actinic keratosis, CD163