Abstract: Objective: To investigate the global disease burden and epidemiological characteristics of urticaria from 1990 to 2019. Methods: Based on the Global Burden of Disease database 2019, we analyzed the global age-standardized incidence rate (ASIR), prevalence rate (ASPR), and age-standardized DALY rate (ASDR) of urticaria from 1990 to 2019 according to the year, sex, age, social index (SDI), the national population and the association between national GDP per capita and disease burden of urticaria was analyzed by Spearman correlation coefficient. Results: The ASIR, ASPR and ASDR of urticaria in females were significantly higher than those in males. The ASIR, ASPR and ASDR of urticaria in children under 5 years old were the highest, and those over 95 years old were the lowest. The burden of urticaria in SDI lower region was higher than high index areas. The first three countries with the highest burden of urticaria in 2019 were Nepal, Poland and Pakistan. National GDP per capita was negatively correlated with ASIR, ASPR and ASDR. Conclusion: Regions and countries with lower levels of development, as well as women and children, have a relatively high burden of urticaria disease.

Key words: urticaria, the burden of disease, epidemiology, socio-demographic index (SDI)