Abstract: Congenital ichthyosis is a keratinization disorder characterized by rough, dry, flaky, and fish scale like skin lesions. It is mostly inherited. There is currently no standardized treatment for this disease. In recent years, some new treatment methods have been reported in the literature, such as targeted drugs, biological agents, gene therapy, enzyme replacement therapy, and nanodelivery therapy. This paper reviews the new progress in the treatment of this disease, aiming to provide references for clinical treatment.

Key words: congenital ichthyosis, biological agents, gene therapy, aminosalicylic acid, enzyme replacement therapy