Abstract: Objective: To assess the efficacy of thalidomide in the treatment of the patients with psoriasis vulgaris and to determine the influence on the level of serum VEGF and bFGF. [WT5”HZ]Methods: Thirty patients with moderate to severe psoriasis vulgaris were treated with oral thalidomide, 100 mg once, twice a day for 8 weeks. The efficacy of treatment was assessed with PASI. The level of VEGF and bFGF in the patients were detected by ELISA before and after treatment. Results: The effective rate of the treatment was 60.00%. The serum level of VEGF and bFGF after treatment were significantly lower than those before the treatment (P＜0.01). The serum level of VEGF and bFGF was positively correlated with PASI scores (P＜0.01).Conclusion: Thalidomide is effective in the treatment of moderate to severe psoriasis and the mechanism may be through inhibiting the serum expression of VEGF and bFGF.

Key words: psoriasis, thalidomide, VEGF, bFGF