Abstract: Protein kinase D1 (PKD1) is one calcium-dependent serine/threonine kinases extensively expressed in multiple important organs and it is involved in multiple physiological processes and various pathological conditions and abnormally expressed in tumor tissues. PKD1 promotes the proliferation and inhibits the differentiation of the keratinocytes, which play an important role in wound healing and tumor development. There is a close correlation between PKD1 and ultraviolet B, ROS, in terms of the development of skin diseases. Therefore, PKD1 may be a more effective target in the treatment of some dermatoses.

Key words: protein kinase D1')">

protein kinase D1, keratinocytes, dermatosis