Abstract: Objective: To assess the efficacy and safety of secukinumab in the treatment of adults patients with moderate-severe psoriasis. Methods: The articles of the randomized, controlled clinical trials about secukinumab in the treatment of moderate-severe psoriasis in adults were searched in PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure, VIP Database for Chinese Technical Periodicals, Wanfang Med Online, and China Biology Medicine disc from the data base establishment to February 2017. The quality of the articles was assessed by two reviewers and meta-analysis was performed using the RevMan 5.3 software. Results: Seven articles including 3474 patients met the criteria. The results of meta-analysis showed that the number of the patients with a decrease of PASI scores up to 75%, 90% and 100% and a score of Investigator's Global Assessment (IGA) of 0 or 1 in 300 mg secukinumab group was more than those treated with 150 mg secukinumab and placebo (P＜0.00001). The adverse reaction in the patients treated with 300 mg and 150 mg secukinumab was higher than those treated with placebo (P＜0.05). However, the difference in adverse reaction was not significant between the patients treated with 300 mg and 150 mg secukinumab. Conclusion: 300 mg secukinumab is more effective in the treatment of moderate-severe psoriasis than 150 mg and there is no significant difference in adverse reaction between the two groups.

Key words: secukinumab, psoriasis, adult, meta-analysis