China Journal of Leprosy and Skin Diseases ›› 2017, Vol. 33 ›› Issue (8): 457-460.

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Efficacy of combination of Holmium laser and photodynamic therapy for the treatment of   refractory basal cell carcinoma and squamous cell carcinoma of head and face

LIU Shengxiu, SHEN Songke, CHEN Jing, XING Linsheng.   

  1. Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
  • Online:2017-08-15 Published:2018-12-04
  • Contact: LIU Shengxiu, E-mail: liushxiu@126.com

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Abstract: Objective: To assess the clinical efficacy of holmium laser combined with photodynamic therapy in the treatment of 19 patients with refractory basal cell carcinoma (BCC) and 7 patients with squamous cell carcinoma (SCC). Methods: Firstly the lesion was removed by holmium laser, then followed by photodynamic therapy. The clinical efficacy was assessed after 12 to 18 months. Results: The lesions were complete remission in 10 cases (8 of BCC, 2 of SCC), partial remission more than 50% in 9 cases (6 of BCC, 3 of SCC) and the total effective rate was 73.08%. Conclusion: Holmium laser combined with photodynamic therapy is effective in the treatment of refractory BCC and SCC on head and face.

Key words: basal cell carcinoma, squamous cell carcinoma, laser, photodynamic therapy, 5-aminolevulinic acid