Abstract: It has been widely accepted that psoriatic arthritis causes bone loss all over the world, but the relationship between plaque psoriasis and osteoporosis is still controversial. Some recent studies have suggested that patients with plaque psoriasis are at increased risk for osteoporosis and even pathological fractures. In this article, we review the possible mechanisms associated with plaque psoriasis and osteoporosis, including the involvement of inflammatory factors, changes in trace elements, drug use and lifestyle changes, which provide theoretical basis for the prevention and treatment of osteoporosis and pathological fractures in patients with plaque psoriasis.

Key words: plaque psoriasis, osteoporosis, pathogenesis, inflammatory factor