Abstract: Eosinophilic pustular folliculitis (EPF) characterized by recurrent sterile papulopustules on the trunk, face, and extremities. We reported a case of EPF treated with omalizumab in this paper. The patient was a 40-year-old female. After being diagnosed with EPF, she was given topical 0.1% tacrolimus ointment for 2 weeks, but it was ineffective. Based on the high recurrence rate and high serum IgE level, omalizumab was used for treatment at a dose of 150 mg per month after obtaining the patient's consent. The skin lesions completely disappeared after 2 months of treatment, and the drug was discontinued after 3 months of treatment. After that, the patient was followed up for one year, and there was no recurrence.

Key words: eosinophilic, pustular folliculitis, omalizumab