Abstract: Lymphoplasmacytic lymphoma/Waldenstr?m macroglobulinemia combined with type I cryoglobulinemia is rare, and we report a case in this paper. A 51-year-old male presented with ulcers on both lower extremities and the scrotum with pain for 8 months. Bone marrow smear showed infiltration of bone marrow plasma cells. Immunophenotyping showed that lymphocytes accounted for 32.5% of the total nucleated cells. Gene detection showed that MYD88L265P gene mutation. After 5 months of treatment with rituximab, the skin lesions were significantly improved.

Key words: skin ulcer, Waldenstr?m macroglobulinemia, lymphoplasmacytic lymphoma, cryoglobulinemia