Abstract: Objective: To assess the efficacy of fractional CO₂ laser in the treatment of primary cutaneous amyloidosis. Methods: The lesions located on the trunk and limbs in the patients with primary cutaneous amyloidosis were treated with fractional CO₂ laser with a pulse energy of 60-80mJ, once every 4 weeks for 3 times. The lesions evaluated according to the size, hyperpigmentation and itching. Results: Ten patients with primary cutaneous amyloidosis (4 patients with lichenoid amyloidosis and 6 patients with macular amyloidosis) were treated with fractional CO₂ laser from Dec. 2017 to Dec. 2018. The scores of lesion size, hyperpigmentation and itching were decreased from 36, 35, 38 to 9, 12 and 4 respectively. The effective rate was 100%, and marked effective rate was 90%. There was no obvious adverse reaction. Conclusion: Fractional CO₂ laser is safe and effective in the treatment of primary cutaneous amyloidosis.

Key words: primary cutaneous amyloidosis, fractional CO₂ laser