中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (6): 446-450.doi: 10.12144/zgmfskin202306446

• 综述 • 上一篇    下一篇

斑秃相关免疫机制研究进展

杨梦瑶,耿龙   

  1. 中国医科大学附属第一医院，沈阳，110000
  • 出版日期:2023-06-15 发布日期:2023-05-19

Update of the immunologic mechanism of alopecia areata

YANG Mengyao, GENG Long   

  1. First Hospital of China Medical University, Shenyang 110000, China
  • Online:2023-06-15 Published:2023-05-19

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摘要： 斑秃是一种以非瘢痕性脱发为特征的自身免疫性皮肤病，其具体病因未明，可能与环境、遗传、免疫等有关。目前普遍认为生长期毛囊“免疫豁免的丧失”在斑秃的发病中起关键作用。近年来斑秃与其他自身免疫病的共同免疫学特性相继被发现，多种新型生物制剂也逐渐被尝试应用于重度斑秃及传统方法疗效不佳者。本文对斑秃相关免疫机制的研究进展进行综述。

关键词: 斑秃, 免疫通路, 细胞因子

Abstract: Alopecia areata (AA) is an autoimmune dermatological disease characterized by non-scarring hair loss, its etiology is still unknown, it could be related to environment, heredity and immunity. It is well accepted that the “loss of immune immunity” of hair follicles during the growth period plays an important role in the etiology of AA. In recent years,  the common immunological characteristics of AA and other autoimmune diseases have been discovered, and a variety of new biological agents have been gradually tried to apply to treat severe AA and those with poor efficacy of traditional therapies. The update of the immunologic mechanism of alopecia areata is reviewed in this paper.

Key words: alopecia areata, immune pathways, cytokines