糖皮质激素治疗进展期白癜风疗效分析

中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (7): 403-406.

糖皮质激素治疗进展期白癜风疗效分析

田军^1,2 朱龙飞^1,3李强¹李舒丽¹ 刘邦民¹ 李春英¹ 高天文¹

1 第四军医大学西京皮肤医院，陕西西安，710032
2 解放军第513医院皮肤科，甘肃酒泉，732750
3 解放军第538医院，陕西汉中，723000

出版日期:2017-07-15 发布日期:2018-12-01
通讯作者: 高天文，E-mail: gaotw@fmmu.edu.cn

Assessment of the efficacy and side effects of systemic corticosteroid in the treatment of patients with progressive vitiligo

TIAN Jun^1,2, ZHU Longfei^1,3, LI Qiang¹, LIShuli¹, LIU Bangmin¹, LI Chunying¹, GAO Tianwen¹

1 Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;
2 Outpatient Department of No.513 Army of PLA, Jiuquan 732750, Gansu, China;
3 No.538 Hospital of PLA, Derpartment of Dermatology, Hospital, Hanzhong 723000, Shanxi, China

Online:2017-07-15 Published:2018-12-01
Contact: GAO Tianwen, E-mail: gaotw@fmmu.edu.cn

摘要/Abstract

摘要： 目的：评价糖皮质激素治疗进展期白癜风的疗效及副作用。方法：甲泼尼龙组进展期白癜风185例（VIDA评分4分，皮损面积>1%），予甲泼尼龙片0.48mg/kg·d口服3日，后0.24 mg/kg·d口服27日，第2个月减为0.12 mg/kg·d，第3个月减为0.12 mg/kg·d;复方倍他米松注射液组107例（VIDA评分3分或4分，皮损面积<1%），成人予复方倍他米松注射液1.0mL，儿童予0.015mL/kg肌肉注射，1次/月，连用3次。结果：治疗3个月后，甲泼尼龙组和复方倍他米松注射液组有效率分别为93.0%和82.3% (P＜0.05)。甲泼尼龙组副作用发生率为82.7%，显著高于复方倍他米松注射液组62.6%(P＜0.05)。结论：系统使用甲泼尼龙治疗进展期白癜风疗效优于倍他米松局部注射，但副作用发生率相应增高。

关键词: 糖皮质激素, 副作用, 进展期, 白癜风

Abstract: Objective: To assess the efficacy and side effects of corticosteroid in the treatment of patients with progressive vitiligo. Methods: One hundred and eighty-five patients with progressive vitiligo (VIDA score of 4 and lesions area>1% body surface?area) were treated with methylprednisolone, 0.48 mg/kg a day for 3 days, and followed by 0.24 mg/kg·d for the rest 27 days of the month. The dosage was decreased to 0.12 mg/kg·d during the second month and 0.06 mg/kg·d during the third month. One hundred and seven patients (VIDA score of 3 or 4 and lesions area<1% body surface area) were treated with compound betamethasone injection, 1.0 mL once a month in adult and 0.015 mL/kg in children for 3 times. Results: The effective rates in the methylprednisolone group and compound betamethasone group were 93.0% and 82.3% respectively, with a significant difference (P＜0.05). The rates of side effects were 82.7% and 62.6% respectively (P＜0.05). Conclusion: Compared to compound betamethasone group the regimen of methylprednisolone treatment is more effective but more side effects.

Key words: corticosteroid, side effect, progressive, vitiligo

田军, 朱龙飞, 李强, 李舒丽, 刘邦民, 李春英, 高天文. 糖皮质激素治疗进展期白癜风疗效分析[J]. 中国麻风皮肤病杂志, 2017, 33(7): 403-406.

TIAN Jun, ZHU Longfei, LI Qiang, LIShuli, LIU Bangmin, LI Chunying, GAO Tianwen.. Assessment of the efficacy and side effects of systemic corticosteroid in the treatment of patients with progressive vitiligo[J]. China Journal of Leprosy and Skin Diseases, 2017, 33(7): 403-406.

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