中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (9): 524-527.

• 论著 • 上一篇    下一篇

Smad7在脂溢性角化病、日光性角化病及基底细胞癌中的表达

和义敏1 章宏峰2 李芃1 梁小芳1 姜小丽1 高英1   

  1. 1.华中科技大学同济医学院附属武汉中心医院皮肤科，湖北武汉，430014 2.华中科技大学同济医学院附属武汉中心医院病理科，湖北武汉，430014
  • 出版日期:2018-09-15 发布日期:2018-12-11
  • 通讯作者: 高英,E-mail: gaoying911@163.com

Expression of Smad7 in seborrheic keratosis, actinic keratosis, and basal cell carcinoma

HE Yimin1, ZHANG Hongfeng2, LI Peng1, LIANG Xiaofang1, JIANG Xiaoli1, GAO Ying1   

  1. 1.Department of Dermatology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China; 2.Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China
  • Online:2018-09-15 Published:2018-12-11
  • Contact: GAO Ying, E-mail: gaoying911@163.com

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摘要： 目的： 检测Smad7在脂溢性角化病、日光性角化病以及基底细胞癌中的表达。方法：对脂溢性角化病、日光性角化病及基底细胞癌标本（各30例）和30例正常标本进行免疫组化染色。结果：23例脂溢性角化病标本、23例日光性角化病标本和28例基底细胞癌标本中Smad7染色阳性，阳性细胞率分别为（31.0±23.0）%，（32.7±26.3）%和（62.6±32.1）%，均显著高于正常组织的（6.7±5.0%）。结论： Samd7可能与脂溢性角化病、日光性角化病以及基底细胞癌的发病有关。

关键词: 脂溢性角化病, 日光性角化病, 基底细胞癌, Smad7, 免疫组化

Abstract: Objective：To detect the expression of Smad7 in the lesions of seborrheic keratosis, actinic keratosis, and basal cell carcinoma. Methods：The levels of Smad7 in the lesions of seborrheic keratosis, actinic keratosis, basal cell carcinoma and normal controls (30 lesions in each group), were detected by immunohistochemical staining. Results：Smad7 was positive in 23 seborrheic keratosis lesions, 23 actinic keratosis lesions and 28 basal cell carcinoma lesions. The positivity rates of Smad7 cells were 31.0±23.0%, 32.7±26.3% and 62.6±32.1% respectively, which were all higher than that in the controls (6.7±5.0%). Conclusions：Smad7 may play a role in the pathogenesis of seborrheic keratosis, actinic keratosis and basal cell carcinoma.

Key words: seborrheic keratosis, actinic keratosis, basal cell carcinoma, Smad7, immunohistochemistry

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