中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (7): 419-423.doi: 10.12144/zgmfskin202107419

• 论著 • 上一篇    下一篇

205例HIV阴性梅毒患者脑脊液白蛋白商数及IgG指数分析

郭泽1,汤华阳1,王再兴1,林达1,李卉1,陈越2,赵煦2,杨森1   

  1. 1安徽医科大学第一附属医院皮肤性病科，合肥，230022；
    2安徽医科大学，合肥，230000
  • 出版日期:2021-07-15 发布日期:2021-06-25
  • 通讯作者: 汤华阳，E-mail: tanghuayang@hotmail.com；李卉，E-mail: 723475415@qq.com

Analysis of albumin quotient and IgG index in 205 HIV-negative syphilis patients

GUO Ze1, TANG Huayang1, WANG Zaixing1, LIN Da1, LI Hui1, CHEN Yue2, ZHAO Xu2, YANG Sen1   

  1. 1 Department of Dermatology and Venereology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; 2 Anhui Medical University, Hefei 230000, China
  • Online:2021-07-15 Published:2021-06-25
  • Contact: TANG Huayang, E-mail: tanghuayang@hotmail.com; LI Hui, E-mail: 723475415@qq.com

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摘要： 目的：了解HIV阴性梅毒患者中脑脊液白蛋白商数及IgG指数的分布特征。方法：共收集205例梅毒患者脑脊液标本，其中124例非神经梅毒, 81例神经梅毒。使用SPSS 25.0 软件进行统计学分析，计算两组患者白蛋白商数及IgG指数的敏感性、特异性及诊断效率。结果：神经梅毒组白蛋白商数及IgG指数分别为(6.98±3.80)和(1.51±1.16)高于非神经梅毒组(4.63±2.03)和(0.67±0.48),差异有统计学意义(均P＜0.001)。在神经梅毒患者中，脑脊液TRUST阳性患者IgG指数均值为(2.14±1.31)较阴性患者（1.10±0.84）高, 差异有统计学意义(P＜0.001)。白蛋白商数在神经梅毒诊断方面，敏感性为73.33%，特异性66.29%，阳性预测值27.16%，阴性预测值93.55%,诊断效率67.32%。IgG指数在神经梅毒诊断方面，敏感性为59.60%，特异性79.25%，阳性预测值72.84%，阴性预测值67.74%,诊断效率69.76%。结论：白蛋白商数及IgG指数可用于神经梅毒的辅助诊断。

关键词: 梅毒, 神经梅毒, 脑脊液, 白蛋白商数, IgG指数

Abstract: Objective: To analyze the albumin quotient (QAlb) and IgG index in HIV-negative syphilis patients. Methods: 205 syphilis inpatients were collected including 124 non-neurosyphilis patients and 81 neurosyphilis patients. The sensitivity, specificity and diagnostic efficiency of  QAlb and IgG index was calculated use SPSS 25.0 software. Results: The QAlb and IgG index were (6.98±3.80) and (1.51±1.16) in the neurosyphilis patients which were higher than that in the non-neurosyphilis patients (4.63±2.03 and 0.67±0.48), with significant differences (P<0.001), the IgG index of the neurosyphilis patients was (2.14±1.31) in TRUST positive group, which was higher than that in negative group (1.10±0.84), with a significant difference (P<0.001). The sensitivity of QAlb and IgG index in the diagnosis of neurosyphilis was 73.33% and 59.60%, specificity was 66.29% and 79.25%, positive predictive value was 27.16% and 72.84%, negative predictive value was 93.55% and 67.74%, and the diagnostic efficiency was 67.32% and 69.76%, respectively. Conclusion: The QAlb and IgG index can be used for the auxiliary diagnosis of neurosyphilis.

Key words: syphilis, neurosyphilis, cerebrospinal fluid, QAlb, IgG index