中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (1): 57-60.doi: 10.12144/zgmfskin202501057

• 病例报告 • 上一篇    下一篇

继发于多发性骨髓瘤的Ⅰ型冷球蛋白血症一例

黄雪沂，郑结成，程云龙，谭敏，廖家   

  1. 中山市第二人民医院，广东中山，528447
  • 出版日期:2025-01-15 发布日期:2024-12-23

Type Ⅰ cryoglobulinemia secondary to multiple myeloma: a case report

HUANG Xueyi, ZHENG Jiecheng, CHENG Yunlong, TAN Min, LIAO Jia   

  1. Department of Dermatology, The Second People's Hospital of Zhongshan, Zhongshan 528447, China
  • Online:2025-01-15 Published:2024-12-23

PDF (PC)

48

摘要： 患者，女，69岁。3个月前确诊多发性骨髓瘤（multiple myeloma，MM），后因天气寒冷诱发四肢末端紫癜、瘀斑伴关节肿痛。检查示血清轻链kappa 显著升高，蛋白固定电泳提示单克隆免疫球蛋白IgG阳性，单克隆kappa轻链（κ）阳性，冷球蛋白血症试验阳性，诊断为继发Ⅰ型冷球蛋白血症。考虑患者冷球蛋白血症与MM疾病活动有关，血液科予以更换化疗方案，局部皮肤外用多磺酸粘多糖乳膏，注意肢端保暖。2个月后患者瘀斑完全消退。

关键词: 多发性骨髓瘤, Ⅰ型冷球蛋白血症, 血管炎

Abstract: A 69-year-old female patient was diagnosed with multiple myeloma (MM) three months ago. Exposure to cold weather triggered symptoms such as purpura, ecchymosis, joint swelling, and pain in her extremities. Her serum light chain kappa levels were notably elevated. Protein fixation electrophoresis positive for monoclonal immunoglobulin IgG, monoclonal kappa light chain (κ), and cryoglobulinemia test. Consequently, secondary type Ⅰ cryoglobulinemia was diagnosed. Given the association between the patient's MM and cryoglobulinemia, the hematology department adjusted the chemotherapy regimen, a topical mucopolysaccharide polysulfate cream was applied to the affected skin areas additionally, and efforts were made to keep her acra warm. After two months, the patient's ecchymosis completely resolved.

Key words: multiple myeloma, type I cryoglobulinemia, vasculitis