中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (4): 314-317.doi: 10.12144/zgmfskin202504314

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毛囊干细胞衰老与脱发相关机制的研究进展

刘慧慧1,王千2,牛旭平2   

  1. 1山西医科大学第九临床医学院皮肤科，山西太原，030009；2山西医科大学附属太原市中心医院皮肤科，山西太原，030009
  • 出版日期:2025-04-15 发布日期:2025-04-09

Update of mechanisms related to hair follicle stem cell aging and hair loss

LIU Huihui1, WANG Qian2, NIU Xuping2   

  1. 1 Department of Dermatology,The Ninth Clinical Medical College of Shanxi Medial University, Taiyuan 030009, China; 2 Taiyuan Central Hospital Affiliated to Shanxi Medical University, Taiyuan 030009, China
  • Online:2025-04-15 Published:2025-04-09

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摘要： 近年来研究表明毛囊干细胞及其微环境在维护组织稳态和调控毛发生长周期中起着关键作用，这一发现为脱发治疗开辟了新的视角和策略。随着年龄的增长，毛囊干细胞的活性和功能会逐渐降低，毛囊的自我修复与再生能力随之下降。本文综述了毛囊干细胞及其微环境的相关内容以及毛囊干细胞衰老的内外机制，以期为脱发治疗带来新的启发。

关键词: 脱发, 毛囊干细胞, 微环境, 衰老

Abstract: In recent years, scientific research has revealed that hair follicle stem cells and their niche play a key role in maintaining tissue homeostasis and promoting hair growth cycle, which opens up new perspectives and strategies for hair loss treatment. With age, the activity and function of hair follicle stem cells gradually decreases, and the ability of hair follicles to self-repair and regenerate is weakened. This paper reviewed the basic contents of hair follicle stem cells and niche, and the internal and external mechanisms of the aging process of hair follicle stem cells, in order to bring new inspirations for the treatment of hair loss.

Key words: hair loss, HFSCs, niche, cell aging