Abstract: Pemphigoid is a term for heterogeneous blistering disorders including bullous pemphigoid(BP), mucous membrane pemphigoid(MMP)，Pemphigoid gestationis(PG), etc. Conventional therapy includes systemic corticosteroids(CS) and immunosuppressive agents(ISA), which is often accompanied by significant adverse reactions after long term treatment. Many scholars have tried to use biological agents to treat pemphigoid and achieved certain efficacy. The update of biological agents in the treatment of pemphigoid is reviewed in this paper.

Key words: pemphigoid, biologicals, rituximab