Abstract:

Objective: To analyze the related factors of the pathogenesis of postherpetic neuralgia, and to provide the basis for the prevention and treatment of PHN. Methods: The clinical data of 199 patients with herpes zoster in Guangzhou First People's Hospital from August 2015 to June 2020 were retrospectively analyzed. According to whether there was neuralgia within 1 month after the rash disappeared, they were divided into PHN group of 57cases, and 142 cases in the non-PHN group. The factors such as age, gender, location, course, clinical classification, acute pain, hemoglobin level, albumin level, glucocorticoid use and whether combined with hypertension and diabetes were analyzed. Statistical analysis was performed using univariate and multivariate logistic regression. Results: Univariate analysis showed that age, course, clinical classification, acute pain, albumin and hemoglobin levels were statistically significant (P<0.05). Hypertension and diabetes were not statistically significant (P>0.05). Multivariate logistic regression analysis showed that the hemoglobin level <120 g/L, age ≥70 years, course≥7 days, clinical types of bullous type, severe pain in acute stage were independent risk factor of PHN. However, low albumin level and lack of glucocorticoid use were not independent risk factors for PHN (P>0.05). Conclusion: The age of patients ≥70 years old, course≥7 days, the degree of acute severe pain, the clinical classification of bullous type, and the hemoglobin level <120g/L are the risk factors for the occurrence of PHN.

Key words: herpes zoster, postherpetic neuralgia, risk factors, low hemoglobin