Abstract: A 42-year-old male presented with erythema, sclerosis, and hair loss for 9 years. Mainly lesions manifested as anomalous plaques, depigmented spots, atrophy, and scars on the chest, limbs and face, hair loss and depigmentation on the top of head. Histopathological manifestations of abdominal lesions showed hyperkeratosis of the epidermis, vacuolar degeneration of basal cells with pigment incontinence, reduction of dermal appendages, thickening of collagen, and hyaline degeneration. The diagnosis of scleroderma-like chronic graft-versus-host disease was made.

Key words: graft-versus-host disease, chronic, scleroderma