Abstract: A six-year-old female was admitted to the hospital due to fever, cough for 3 days and skin rash for 3 hours. She got the second dose of COVID-19 vaccine before the onset of the skin disease. After admission, her lesions increased gradually, and the erosion on her eyes, oral mucosa, perianal mucosa, vulva and other mucous membranes appeared, accompanied by persistent high fever. Epidermal necrolysis on her head, face, neck, trunk and limbs occurred. The affected area of epidermal necrolysis accounted for 66% of the body surface area. The diagnosis of a toxic epidermal necrolysis was made. She was cured and discharged from hospital after 36 days of comprehensive treatment including the pulse therapy with methylprednisolone, injection of high-dose human immunoglobulin, and plasma exchange.

Key words: COVID-19 vaccine, toxic epidermal necrolysis, child