中毒性表皮坏死松解症病因及发病危险因素研究进展

doi:10.12144/zgmfskin202305382

Abstract

Abstract: Toxic epidermal necrolysis(TEN) is a skin-mucosal reaction that can be life-threatening. Drugs are the main cause of SJS/TEN. Pharmacogenomics reveals that HLA genes are closely related to SJS/TEN caused by aromatic anticonvulsants and non-steroidal anti-inflammatory drugs(NSAIDs). Cytochrome P450(CYP450）variants can cause slow drug metabolism and increase the risk of SJS/TEN. Immune checkpoint inhibitors can cause skin immune-related adverse effects, including SJS/TEN. Human herpes virus, Epstein-Barr virus, Mycoplasma pneumoniae and other infectious factors are related to the development of SJS/TEN. Other factors such as autoimmune diseases and active cancer are also potential risk factors for SJS/TEN. The update of etiology and risk factors of toxic epidermal necrolysis was reviewed in this paper.

Key words: toxic epidermal necrolysis, etiology, risk factors

GAO Lan, LAO Limin. Update of etiology and risk factors of toxic epidermal necrolysis[J].China Journal of Leprosy and Skin Diseases, 2023, 39(5): 382-386.

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Update of etiology and risk factors of toxic epidermal necrolysis

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