Abstract: A 66-year-old male presented with multiple papules and maculae for 3 years, aggravated with severe pruritus for more than 2 months. The diagnosis of inflammatory disseminated superficial porokeratosis was made according the features of manifestation and biosy. The conventional therapy was ineffective, and then, the patient was given tofacitinib 5 mg orally twice a day. After the treatment of one month, most of the the rash subsided, and the itching was relieved.

Key words: tofacitinib, inflammatory, porokeratosis, disseminated superficial