Abstract: DNA methylation is a common modification pathway in epigenetics, which is closely related to the pathogenesis of various skin disorders. T cells include CD8+ T cells, CD4+ T cells and so on, which involve in immune responses and work as important regulatory cells in the development of skin diseases such as psoriasis, systemic lupus erythematosus, systemic scleroderma, and primary Sjogrens syndrome. The update on the pathogenesis and research progress of these diseases, particularely from the point view of DNA methylation in T cells, is made.

Key words: T cells, DNA methylation, skin disorders