程序性细胞死亡因子-1在过敏性疾病中的研究进展

doi:10.12144/zgmfskin202005307

China Journal of Leprosy and Skin Diseases ›› 2020, Vol. 36 ›› Issue (5): 307-312.doi: 10.12144/zgmfskin202005307

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The role of programmed cell death-1 in allergic diseases

HAN Yue, YAO Xu

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China

Online:2020-05-15 Published:2020-05-28
Contact: YAO Xu, E-mail: dryao_xu@126.com

Abstract

Abstract: Programmed death -1 (PD-1) is one of the members of CD28 family molecules expressed on the surface of a variety of immune cells. PD-1 has traditionally been considered as a negative regulator of CD4+T cells. However, its role in regulating the activities and function of T cells has been gradually revealed in recent years. Studies have shown that the ligands of PD-1, PD-L1 and PD-L2 can regulate the activation and tolerance of T cells. The role of PD-1 and its ligands in allergic diseases is reviewed in this paper.

Key words: PD-1, allergic diseases, ligands, T cells

HAN Yue, YAO Xu. The role of programmed cell death-1 in allergic diseases[J].China Journal of Leprosy and Skin Diseases, 2020, 36(5): 307-312.

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The role of programmed cell death-1 in allergic diseases

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