Abstract: Objective: To compare the clinical features and laboratory index between symptomatic and asymptomatic neurosyphilis in HIV-infected patients. Methods: The data of human immunodeficiency virus (HIV) infection who were hospitalized in our hospital from January 2016 to June 2022 were analyzed. They were divided into symptomatic neurosyphilis (SNS) and asymptomatic neurosyphilis (ANS) group according to clinical symptoms and signs. The clinical characteristics, imaging data, serology, and cerebrospinal fluid laboratory characteristics were retrospectively analyzed. Results: A tall of 110 neurosyphilis cases were analyzed, including 67 in SNS group (65 males and 2 females), with an average age of (38.22±11.73) years, and 43 in ANS group (42 males and 1 female), with an average age of (36.86±11.76) years. The proportions of patients with a history of antisyphilitcic treatment and antiviral therapy in SNS group were significantly lower than that in ANS group (P<0.05). The WBC count, protein quantification, TRUST positive rate and titer level of CSF in SNS group were higher than that in ANS group separately (Ps<0.05). There were no significant differences in serum CD4+T lymphocyte count, TRUST abnormality rate, TRUST titer level between the two groups (Ps>0.05). Conclusion: The level of cerebrospinal fluid inflammatory indicators in the patients with symptomatic neurosyphilis is higher. SNS are more likely to occur in patients with HIV who have no history of antisyphilitcic or antiretroviral therapy.

Key words: neurosyphilis, human immunodeficiency virus, symptomatic, asymptomatic