阿布昔替尼,皮肤扁平苔藓,JAK抑制剂," /> 阿布昔替尼,皮肤扁平苔藓,JAK抑制剂,"/> abrocitinib, cutaneous lichen planus, JAK inhibitors,"/> Abrocitinib in the treatment of cutaneous lichen planus: two cases and literature review

China Journal of Leprosy and Skin Diseases ›› 2024, Vol. 40 ›› Issue (6): 412-415.doi: 10.12144/zgmfskin202406412

• Clinical Researches • Previous Articles     Next Articles

Abrocitinib in the treatment of cutaneous lichen planus: two cases and literature review

CUI Yinling1,2, XU Fanli1,2, CAO Shan1,2, XUE Xiaotong1,2, ZHAO Qing1,2, LIU Yongxia1,2, LIU Hong1,2, ZHANG Furen1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022,China
  • Online:2024-06-15 Published:2024-05-07

Abstract: Conventional treatment of lichen planus includes oral glucocorticosteroids, methotrexate, and Acitretin. The use of these drugs is often limited by their adverse effects. JAK inhibitors regulate immunity by inhibiting the JAK-STAT pathway and affecting the function of cytokines such as INF-γ. In this paper, we report two cases of effective cutaneous lichen planus treated with JAK1 inhibitor abrocitinib and review the relevant literature.

Key words: abrocitinib')">">abrocitinib, cutaneous lichen planus, JAK inhibitors