Abstract: Generalized pustular psoriasis is characterized by erythema and sterile pustules on the skin, and hair loss is uncommon. This paper presents a case of a patient with plaque psoriasis who showed significant improvement after being treated with secukinumab. However, after discontinuing the treatment for a period of time and then receiving it again, the condition evolved into generalized pustular psoriasis and extensive alopecia occurred. After switching to deucravacitinib treatment, both the psoriasis and alopecia were significantly improved.

Key words: deucravacitinib, generalised pustular psoriasis, alopecia, secukinumab