中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (1): 58-60.

• 综述 • 上一篇    下一篇

靶向生存素shRNA在肿瘤治疗中的研究进展

张 鑫 郝玉琴   

  1. 内蒙古医科大学第三附属医院,包头,014010
  • 出版日期:2016-01-15 发布日期:2018-12-13
  • 通讯作者: 郝玉琴 Email:haoyuqin0472@163.com
  • 基金资助:
    基金项目:国家自然科学基金资助项目(编号:81260407)

Update of shRNA targeting survivin in the treatment of tumor

ZHANG Xin, HAO Yu-qin   

  1. Department of Dermatology, Third Affiliated Hospital of Inner Mongolia Medical University, Baotou 014010, China
  • Online:2016-01-15 Published:2018-12-13
  • Contact: HAO Yu-qin,Email: haoyuqin0472@163.com

摘要: 生存素在细胞凋亡抑制中起重要作用,越来越多的研究者将其作为肿瘤基因治疗的理想靶点。应用RNA干扰技术靶向抑制生存素的表达,从而抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、抑制肿瘤血管生成、增强肿瘤细胞对放化疗的敏感性。

关键词: 生存素, shRNA, 肿瘤

Abstract: [Abstract] Survivin plays an important role in the inhibitor of apoptosis, which is considered as an ideal target for tumor treatment by more and more researchers. shRNA interference technique is targeted on the inhabiting the expression of survivin , so that inhibiting the proliferation of tumor cells, inducing the apoptosis of tumor cells, inhibiting the angiogenesis of tumor and enhancing the sensitivity of tumor cells to radiotherapy and chemotherapy.

Key words: surviving, shRNA, tumor