Merkel细胞癌合并原位鳞状细胞癌一例并文献复习

doi:10.12144/zgmfskin202205307

Abstract

Abstract: Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroendocrine carcinoma that primarily arises on skin of head and neck (41%-50%), followed by lower limbs and upper extremities (32%-38%). MCC is susceptible in elderly persons. MCC may occur concurrently with squamous cell carcinoma, Bowen disease, basal cell carcinoma, and (or) other cutaneous malignancies. We report a case of Merkel cell carcinoma with squamous cell carcinoma in situ in a non-photoexposed site and review the related literature.

Key words: merkel cell carcinoma, squamous cell carcinoma

ZHU Huiying, ZHANG Zhaoxia, ZHOU Guizhi, WANG Jianwen, CHEN Shengli. Merkel cell carcinoma combined squamous cell carcinoma in situ: a case report and literature review[J].China Journal of Leprosy and Skin Diseases, 2022, 38(5): 307-309.

[1]	KONG Xiaoyun, MIAO Xu, ZHANG Dongmei, CUI Hengxiang, SHI Jian, LIU Niannian. Expression of prohibitins 2 in cutaneous squamous cell carcinoma and its effect on proliferation of cutaneous squamous cell carcinoma cell line A431 [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(8): 499-505.
[2]	LIU Jianxia, XIE Hui, MIAO Guoying. 5-Aminolevulinic acid photodynamic therapy in the treatment of squamous cell carcinoma of the face: a case report [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(8): 529-530.
[3]	WU Riga, HE Wei, LI Yan. Generalized porokeratosis accompanied with squamous cell carcinoma: a case report [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(3): 170-171.
[4]	GU Hongzhi, ZHANG Lian, YANG Haichao, YANG Xichuan, WANG Juan. Subungual squamous cell carcinoma misdiagnosed as paronychia: a case report [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(12): 803-804.
[5]	LI Xiaomin, LIANG Weiwei, HAN Dong, LIU Aiqin, HAN Zhiqiang. Effect of grape seed proanthocyanidin on proliferation and apoptosis of human skin squamous cell carcinoma A431 cells [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(11): 696-699.
[6]	QIAO Li, LI Qiang, CAI Hong, TIAN Rong, YANG Zhiyong, MEI Zhusong, LI Fei. Effects of exogenous signal transduction pathway JAK/STAT on apoptosis of human SCC cells induced by ALA-PDT [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(8): 473-478.
[7]	ZHANG Fuhe, SU Ting, YIN Zhi, SU Zhonglan. Squamous cell carcinoma secondary to Bowen's disease: a case report [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(7): 422-423.
[8]	HU Jie, CHEN Wei, LU Ping, CHENG Shuanghua, LI Can. The expression of PD-L1 level in cutaneous squamous cell carcinoma and keratoacanthoma [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(6): 335-338.
[9]	CHANG Lu, YANG Jie, JIANG Feng, BI Tingmin. Squamous cell carcinoma with giant horn on face: a case report [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(6): 350-351.
[10]	CHAO Lumen, ZHANG Shifa. Expression of Axin1, Gsk-3β and CD82 in cutaneous squamous cell carcinoma [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(11): 658-662.
[11]	WANG Xiaoqing, LIU Zhenru, LIU Mengxi, ZHOU Yuan, WANG Daguang. The evaluation and treatment of primary cutaneous squamous cell carcinoma with lymph node metastasis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(11): 701-704.
[12]	YI Meihui, CHEN Bin, QIU Ying. Unclosed wound surgery combined with photodynamic therapy for SCC-KA: a case report [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(1): 51-52.
[13]	YANG Liya, LIU Caiyu. Sulforaphane inhibits the proliferation of skin squamous cell carcinoma A431 cells through down-regulating Cox-2/Akt/GSK3β cascade [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(8): 476-479.
[14]	WEI Yun, WU Lijuan, DING Gaozhong, FENG Yumiao, SUN Lan. Expression of caveolin-1 and Met protein in actinic keratosis, Bowen disease and cutaneous squamous cell carcinoma tissues [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(5): 276-279.
[15]	LYU Jun, LEI Shuying. Quercetin inhibits the proliferation of human skin squamous cell carcinoma A431 cells through sphingosine kinase 2 [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(12): 722-726.

Merkel cell carcinoma combined squamous cell carcinoma in situ: a case report and literature review

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