Abstract: Mycobacterium chelae infection can be occurred after surgery or trauma, and may also be related to the use of immunosuppressive medicine. The manifestations lacks of specificity. It requires a combination of antibiotics and a full course of treatment. We report a case of facial tumescent lupus erythematosus complicated with Mycobacterium chelae infection. The diagnosis was confirmed by skin biopsy and qPCR sequencing. The patient was cured by clarithromycin and linezolid.

Key words: Non-tuberculous Mycobacteria, Mycobacterium chelae, granuloma, sequencing, clarithromycin, linezolid