Abstract: Subcutaneous granuloma annularis is a non-infectious granulomatous skin disease characterized by subcutaneous nodules. It is rare in clinic and occurs mostly in children, but rarely in adults. Herein, we report a case of of adult generalized subcutaneous granuloma annulare, and the evolution of disease is unique in this patient. A 61-year-old female presented with nodules on abdominal and bilateral feet for 2 months and the whole body was generalized for more than 1 month. In this case, subcutaneous skin nodules were present in the initial clinical stage, which gradually evolved into dark red nodules and finally dark red patches. The cutaneous histopathology showed that the location of palisade granuloma was also from deep to shallow, from the subcutaneous fat layer to the whole dermis layer, showing a corresponding relationship with clinical manifestations.

Key words: granuloma annulare, subcutaneous type, adult