Abstract: Objective: To To investigate syphilis infection among new drug men who have sex with men (MSM) in Tianjin. Methods: From October 2020 to September 2021, MSM using new drugs were recruited through a combination of online and offline recruitment. Basic demographic information, sexual behavior, and new drug use were collected. Statistical tests were used to compare the characteristics of syphilis infected and non-infected MSM using novel drugs. Results: A total of 416 MSM using novel drugs were included in the study, ranging in age from 20 to 70 years old, with an average age of 35.17±9.41 years old. 107 patients were infected with syphilis, the infection rate was 25.72%. The most common drug was Rush Popper. There were statistically significant differences in age (P=0.003), marital status (P=0.024), working status (P=0.001), awareness of HIV status (P=0.021), and condom use during last anal sex (P=0.020) among patients with syphilis and non-infected persons. Failure to use a condom during the most recent anal intercourse was a risk factor for syphilis in this population (OR=2.416). Conclusion: The infection rate of syphilis in MSM using new drugs in Tianjin is at a high level.

Key words: syphilis, men who have sex with men, recreational drugs, HIV