Abstract: We report a case of a patient with pyoderma gangrena for 17 years. The patient has been hospitalized in our department for 18 times. He has been treated with glucocorticoids, immunosuppressants, esepil, thalidomide and other drugs and physical therapy, and the skin ulcer can be improved, but there are still repeated. The patient's condition worsened half a month ago, and he was treated with glucocorticoid combined with adalimumab. After 2 weeks, the ulcer became shallow and he was discharged. After discharge, methylprednisolone 50 mg was taken orally once a day and gradually reduced, and adalimumab 40 mg was taken orally once every 2 weeks. Most of the ulcers healed after the fourth injection of adalimumab. After 8 months of follow-up, the patient had stopped taking glucocorticoid, maintained treatment with adalimumab, and the skin lesions were basically cured.

Key words: pyoderma gangrenosum, adalimumab, glucocorticoids