Abstract: Objective: To investigate the awareness and acquisition of knowledge on leprosy in Qianxinan, Guizhou. Methods：The information on the knowledge of leprosy was collected with a questionnaire administered by stratified random sampling in eight counties of Qianxinan. Results：A total of 15145 people were investigated, including 7996 farmers, 6044 students and 1105 leprosy household contacts. Nine thousands nine hundred and ninety-three respondents got more than 5 correct answers and the awareness rate was 65.98% in total. The awareness rate in household contact group was 75.93%, which was higher than that in farmers (63.36%) and students (67.64%). The approaches included public propaganda (47.08%), public health education materials (45.46%) and information on leprosy in TV (30.66%). Conclusion：The awareness rate in household contact group was higher. The main approaches were public propaganda and public health education materials.

Key words: leprosy, awareness rate, health education