中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (12): 709-712.

• 论著 • 上一篇    下一篇

XIAP和caspase-9在尖锐湿疣组织中的表达

李晶1 ，徐洪玉1 ，吴振涛2   

  1. 1山东省交通医院皮肤科，济南，250031；2 山东省青州市皮肤病防治站，青州， 262500
  • 出版日期:2016-12-15 发布日期:2018-12-20
  • 通讯作者: 李晶，E-mail: lijing810222@126.com

The expression of XIAP and Caspase-9 in condyloma acuminatum

LI Jing1, XU Hongyu1,WU Zhentao2   

  1. Department of Dermatology, Shandong Jiaotong Hospital, Jinan, 250031, China
  • Online:2016-12-15 Published:2018-12-20
  • Contact: LI Jing, E-mail：lijing810222@126.com

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摘要： 目的：检测XIAP和caspase-9在CA组织中的表达。方法：采用免疫组化方法分别检测72例CA组织和20例正常包皮组织中XIAP和caspase-9蛋白的表达。结果：CA组织中XIAP蛋白的阳性表达率（56.94％）高于对照组（15.00％），其差别有统计学意义（P＜0.05）；而caspase-9蛋白的阳性表达率（37.50％）较对照组（70.00％）低，其差别亦有统计学意义（P＜0.05）。两种蛋白在CA组织中的表达呈负相关(r=-0.83，P＜0.05)。结论：XIAP抑制caspase-9的活性和表达，两者共同参与CA的发病过程。

关键词: 尖锐湿疣, XIAP, caspase-9, 凋亡

Abstract: Objective: To detect the expression of XIAP and Caspase-9 in condyloma acuminatum. Methods: The immunohistochemistry method was used to detect the expression of XIAP and Caspase-9 in the tissues of 72 patients with condyloma acuminatum and prepuce tissues of 20 healthy persons. Results: The positive rate of XIAP protein in condyloma acuminatum was significantly higher than that in normal prepuces (56.94% vs 15%, P＜0.05), while the positive rate of Caspase-9 protein in condyloma acuminatum was lower than that in normal prepuces (37.5% vs 70%, P＜0.05). There was a negative correlation between the expression of XIAP and Caspase-9 (r=-0.83 P<0.05). Conclusion: XIAP may promote the development of condyloma acuminatum by inhibiting the activity of Caspase-9. The abnormal expression of XIAP and Caspase-9 may be involved in the progression of condyloma acuminatum．

Key words: condyloma acuminatum, XIAP, Caspase-9, apoptosis