protein kinase D1,keratinocytes,dermatosis ,"/> 皮肤病中蛋白激酶D1研究进展

中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (5): 304-307.

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皮肤病中蛋白激酶D1研究进展

顾静1  刘保国2  周萌1  张海芳3   

  1. 1承德医学院研究生学院，承德，067000
    2河北工程大学附属医院皮肤科，邯郸，056000
    3邯郸市紧急救援指挥中心，河北邯郸，056000
  • 出版日期:2017-05-15 发布日期:2018-12-26
  • 通讯作者: 刘保国，E-mail：lbg66@163.com

Update of protein kinase D1 in dermatosis

GU Jing1, LIU Baoguo2, ZHOU Meng1, ZHANG Haifang3.   

  1. 1. Institute of Postgraduate Department of Chengde Medical College, Chengde 067000, China; 
    2. Department of Dermatology, the offiliated Hospital of Hebei Engineering University, Handan 056000, China;
    3. Handan Command Center of Emergency Ressue, Handan 056000, China
  • Online:2017-05-15 Published:2018-12-26
  • Contact: LIU Baoguo, E-mail: lbg66@163.com

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摘要： 蛋白激酶D1是一种在体内多个重要器官广泛表达的钙离子/钙调蛋白依赖性的丝氨酸/苏氨酸蛋白激酶，参与多种重要的生理和病理活动，在许多肿瘤组织中表达异常。PKD1促进角质形成细胞增殖,抑制其分化，对表皮伤口愈合及肿瘤的形成具有促进作用，与UVB、ROS等影响皮肤疾病发生发展的重要因素之间都有密切联系。因此PKD1可能成为治疗某些皮肤病甚至皮肤肿瘤更有效的分子靶点。

关键词: 蛋白激酶D1, 角质形成细胞, 皮肤疾病

Abstract: Protein kinase D1 (PKD1) is one calcium-dependent serine/threonine kinases extensively expressed in multiple important organs and it is involved in multiple physiological processes and various pathological conditions and abnormally expressed in tumor tissues. PKD1 promotes the proliferation and inhibits the differentiation of the keratinocytes, which play an important role in wound healing and tumor development. There is a close correlation between PKD1 and ultraviolet B, ROS, in terms of the development of skin diseases. Therefore, PKD1 may be a more effective target in the treatment of some dermatoses.

Key words: protein kinase D1')">

protein kinase D1, keratinocytes, dermatosis