中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (8): 457-459,463.

• 论著 • 上一篇    下一篇

MMP-12及其抑制因子TIMP-1在基底细胞癌和鳞状细胞癌患者皮损中的表达

司海鹏, 高丽丽 , 王剑蓉   

  1. 南京中医药大学附属医院，南京，210029
  • 出版日期:2018-08-15 发布日期:2018-12-11
  • 通讯作者: 司海鹏，E-mail：mtshp@sina.com.cn

Expression of matrix metalloproteinase-12 and its tissue inhibitor-1 in the lesions of BCC and SCC

SI Haipeng, GAO Lili, WANG Jianrong   

  1. Department of Pathology, Affiliated Hospital of Nanjing Traditional Chinese Medicine University, Nanjing, 210029
  • Online:2018-08-15 Published:2018-12-11
  • Contact: SI Haipeng，E-mail：mtshp@sina.com.cn

PDF (PC)

150

摘要： 目的：明确基质金属蛋白酶-12(MMP-12)及其抑制因子-1（TIMP-1）与基底细胞癌（BCC）和鳞状细胞癌（SCC）的相关性。方法：通过免疫组化法检测MMP-12及TIMP-1在20例正常皮肤组织（NC）和31例基底细胞癌（BCC）、25例皮肤鳞状细胞癌患者（SCC）皮损中的表达。结果： MMP-12、TIMP-1在BCC和SCC中均呈弥漫性阳性表达。MMP-12在BCC和SCC患者中表达阳性率分别为45.2% 和80%，高于正常组的5%(P＜0.05),TIMP-1在BCC和SCC患者中表达阳性率分别为67.7%和60%，低于正常组的90%（P＜0.05）。结论：MMP-12、TIMP-1蛋白可能在BCC和SCC发病中发挥重要作用。

关键词: 基底细胞癌, 皮肤鳞状细胞癌, 基质金属蛋白酶-12, 基质金属蛋白酶组织抑制因子-1

Abstract: Objective: To determine the expression of matrix metalloproteinase-12 (MMP-12) and its tissue inhibitor-1 (TIMP -1) in basal cell carcinoma (BCC) andcutaneous squamous cell carcinoma (SCC). Methods: The expression of MMP-12 and TIMP-1 proteins from the paraffin embedded sections of 25 patients with SCC, 31 patients with BCC and 20 normal controls were detected by immunohistochemical method. Results：The positivity rates of MMP-12 were 45.2% in the samples of BCC and 80% in SCC, which was higher than that in controls（P ＜0.05）. The positivity rates of TIMP -1 were 67.7% in the samples of BCC and 60% in SCC, which was lower than that in controls (P＜0.05). Conclusions: The high expression of MMP-12 and low expression of TIMP-1 may be associated with the development of SCC and BCC.

Key words: basal cell carcinoma, squamous cell carcinoma, matrix metalloproteinase-12, tissue inhibitor of metalloproteinase-1