Abstract: Objective: To systematically evaluate the positivity rates to antimicrobial agents of Propionibacterium acnes (P.acnes) isolated from patients with acne in China and to provide a clinical reference for the antibiotic therapy of acne. Methods: The relevant studies were searched from CNKI, Quotation Databases of Chinese Science and Technology Periodical (VIP), Wanfang Data and PubMed and analyzed with Meta analysis through R3.3.2 Meta software package. Results: A total of 13 articles were enrolled, including 1770 patients with acne, 1259 bacterial strains of P.acnes. The drug resistance rates of P.acnes to Erythromycin, Clarithromycin, Azithromycin were 45%（95% CI 0.35～0.58)，74%（95% CI 0.51～0.89)，59%（95% CI 0.33～0.84) respectively；the drug resistance rates of P.acnes to minocycline, doxycycline, tetracycline were 2%（95% CI 0.00～0.07)，6%（95% CI 0.00～0.26)，8%（95% CI 0.00～0.24) respectively；the drug resistance rate of P.acnes to Metronidazole was 96% (95% CI 0.80～1.00) and there was cross resistance between different antibiotic classes. Conclusion: There was a high drug resistance rates of P.acnes isolated from patients with acne to macrolides and Metronidazoles and P.acnes was sensitive to etracyclines, minocycline was at maximum sensitivity.

Key words: acne, propionibacterium acnes, positivity to antimicrobial agents, systematic analysis