Abstract: As the largest organ of the human body, the skin covering the body surface is susceptible to the influence of microorganisms, chemical, physical, and immune factors to cause troublesome skin diseases. The excessive oxidants can lead to oxidative stress and chronic inflammation in the body, which may lead to the occurrence and development of various skin diseases, including psoriasis, atopic dermatitis, delayed healing and non-union of wounds, and aging. Hydrogen molecule can selectively scavenge hydroxyl free radicals and peroxynitrite anions without affecting the physiological functions of reactive oxygen species, which has anti-inflammatory, anti-oxidant, and anti-apoptotic effects. The action mechanism of hydrogen molecules and application in treatment for skin diseases are reviewed.

Key words: hydrogen molecule, ROS, dermatology