Abstract: The multi-channel transmembrane protein UNC93B1 is an endoplasmic  reticulum resident protein that can transport TLR3, TLR7, TLR8, TLR9 and TLR13 from the endoplasmic reticulum to their final cellular location. They recognize nucleic acids and localize in endosomes. The missense mutation in UNC93B1 disrupts the balance of TLR levels in the endosome and can lead to autoimmunity. Systemic lupus erythematosus is an autoimmune disease that can affect multiple organs such as the skin, heart, and kidneys, leading to serious organ complications and even death. This paper systematically reviews the role of intracellular UNC93B1 and TLR7 in systemic lupus erythematosus, which may provide a new treatment approach for SLE and other autoimmune diseases.

Key words: UNC93B1, TLR7, lupus erythematosus, systemic, pathogenic mechanism, therapy